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Tampa, FL, USA

Scientific Advisory Board

Scott Antonia, M.D., Ph.D. (Chair)

Scott Antonia, M.D., Ph.D., is the Director of the Duke Cancer Institute's Center for Cancer Immunotherapy and serves as an instructor in the Duke University School of Medicine in Durham, North Carolina. Dr. Antonia was formerly the Chair of the Thoracic Oncology Department at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. Dr. Antonia originally joined the Moffitt Cancer Center in 1994 and previously served as the Associate Chair of the Sarcoma Department. 


Dr. Antonia’s work focuses on translational research. Using his molecular biology and cellular background in the development of immunotherapeutic strategies for the treatment of cancer patients, he has developed strategies designed to thwart the immunosuppressive mechanisms used by tumors to evade T-cell mediated rejection. His clinical interests focus on immunotherapy and immunobiology, in particular, gene-modified tumor cell vaccine trials at both pre-clinical and clinical stages. He has designed and conducted numerous cutting-edge studies with novel immunotherapeutics and has two patents for technology he has developed. In addition, as a researcher and practitioner, Dr. Antonia has served as a Principal Investigator for several major clinical trials and has authored dozens of publications in peer-review journals. 


Dr. Antonia's work and expertise in the field of immunology dates back to the beginning of his career and education. Dr. Antonia received his M.D. and his Ph.D. in Immunology from the University of Connecticut Health Center in Farmington, Connecticut. In addition, he completed an internal medicine residency at Yale University School of Medicine and pursued additional training at Yale through a medical oncology fellowship and post-doctoral fellowship in Immunobiology.

Darrell Irvine, Ph.D.


Darrell Irvine, Ph.D., is a Professor at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. He also serves on the steering committee of the Ragon Institute of MGH, MIT, and Harvard.  His research is focused on the application of engineering tools to problems in cellular immunology and the development of new materials for vaccine and drug delivery. Current efforts are focused on problems related to vaccine development for HIV and immunotherapy for cancer.  Dr. Irvine’s work has been recognized by numerous awards, including a Beckman Young Investigator award, an NSF CAREER award, selection for Technology Review’s ‘TR35’, election as a Fellow of the Biomedical Engineering Society, election as a fellow of the American Institute for Medical and Biological Engineering, and appointment as an investigator of the Howard Hughes Medical Institute.  He is the author of over 100 publications, reviews, and book chapters and an inventor on numerous patents. Darrell Irvine is a Professor at MIT with Howard Hughes Medical Institute/Koch Institute for Integrative Cancer Research.

Stefani Spranger, Ph.D.


Dr. Stefani Spranger is an Assistant Professor at the Koch Institute for Integrative Cancer Research and Department of Biology at Massachusetts Institute of Technology. Dr. Spranger is widely regarded as an expert in cancer immunology and cancer biology. During her postdoctoral training at the University of Chicago, under the supervision of Dr. Thomas F. Gajewski, Dr. Spranger made the novel discovery that tumor cell-intrinsic activation of the oncogenic Wnt/ β-catenin pathway results in exclusion of T cells from the tumor micro-environment. This groundbreaking work has been published in Nature and she has co-authored significant scientific papers on key immunotherapeutic targets such as IDO, STING, Tregs and checkpoint inhibitors. She is the current chair of the ESC committee for SITC (Society for Immunotherapy of Cancer) and winner of the 2015 Wissler Fellowship Award at University of Chicago.

Paul Rennert, Ph.D.


Paul Rennert, Ph.D., is an experienced biotechnology executive and seasoned researcher with extensive strategic and leadership experience. Dr. Rennert has  demonstrated success in bench to IND development of small molecule and biologic drugs for oncology, autoimmunity, chronic inflammation and fibrosis, primarily as a Principal Scientist at Biogen. His recent accomplishments include working intensively with Co-Stim Pharmaceuticals' executive team to prioritize and build the company's immunotherapy portfolio, which was acquired in 2014 by Novartis. He is the editor of the newly released book, Novel Immunotherapeutic Approaches to the treatment of Cancer: Drug Development and Clinical Application.

Edith Janssen, Ph.D.

Edith Janssen, Ph.D., currently serves as the Associate Director for Immunology at Janssen Pharmaceuticals, a division of Johnson & Johnson. Dr. Janssen is an expert in innate immunology. She collaborated with Dr. Bruce Beutler (Nobel Prize in Medicine, 2011) to understand the relationship between innate and adaptive immunity, which had historically been viewed as separate entities. The novel concept of innate-adaptive immune interaction significantly contributed to the optimization of vaccines, cancer therapies, and therapies targeting autoimmunity, transplantation, and infection. Her pioneering work in defining the role of CD4+T cell in CD8+T cell priming and memory development, a long-standing paradox in cellular immunology was published in Nature and Nature Immunology. 

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